Alteration in binding of dexamethasone to glucocorticoid receptors in regenerating rat liver after partial hepatectomy.
نویسندگان
چکیده
Changes in binding of dexamethasone (9 alpha-fluoro-11 beta, 17 alpha, 21-trihydroxy-16 alpha-methylpregna-1,4-diene-3,20-dione) to its receptors in regenerating rat liver after 70% hepatectomy were examined. Specific receptors for dexamethasone in the liver remnants of adrenalectomized rats decreased significantly during the period of DNA synthesis after 70% hepatectomy; then, they increased to above the control values between Days 4 and 7 after partial hepatectomy and subsequently returned to the control values. During the period of DNA synthesis, decreased binding was observed in partially hepatectomized rats with or without adrenals, but later enhanced binding was not prominent in rats with adrenals.
منابع مشابه
Effect of glucocorticoid on liver regeneration after partial hepatectomy in the rat.
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عنوان ژورنال:
- Cancer research
دوره 39 12 شماره
صفحات -
تاریخ انتشار 1979